Protein Name PRAME nuclear receptor transcriptional regulator
Organism Homo sapiens
Gene ID 23532
Gene Symbol

PRAME

UniProt P78395 (PRAME_HUMAN), A0A024R1E6 (A0A024R1E6_HUMAN), B7Z986 (B7Z986_HUMAN), B7ZAT0 (B7ZAT0_HUMAN), B7Z7K8 (B7Z7K8_HUMAN)
Relationships Total Number of functionally related compound(s) : 40
Total Number of Articles : 45
Description

PRAME nuclear receptor transcriptional regulator

Gene Summary

This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

synonyms
  • melanoma antigen preferentially expressed in tumors
  • Opa-interacting protein OIP4
  • cancer/testis antigen 130
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Properties