| Protein Name | NPHS1 adhesion molecule, nephrin |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 64563 |
| Gene Symbol | Nphs1 |
| UniProt | Q9R044 (NPHN_RAT), A0A140TAG4 (A0A140TAG4_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
146
Total Number of Articles : 189 |
Description |
NPHS1 adhesion molecule, nephrin |
| Gene Summary |
Enables alpha-actinin binding activity; protein domain specific binding activity; and spectrin binding activity. Predicted to be involved in several processes, including myoblast fusion; skeletal muscle tissue development; and slit diaphragm assembly. Predicted to act upstream of or within several processes, including JNK cascade; cell adhesion; and positive regulation of actin filament polymerization. Located in basement membrane; plasma membrane; and slit diaphragm. Part of protein-containing complex. Biomarker of end stage renal disease; kidney failure; membranous glomerulonephritis; and nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 1. Orthologous to human NPHS1 (NPHS1 adhesion molecule, nephrin). [provided by Alliance of Genome Resources, Jun 2025] |
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