| Protein Name | bone morphogenetic protein 4 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 12159 |
| Gene Symbol | Bmp4 |
| UniProt | P21275 (BMP4_MOUSE), Q3ULR1 (Q3ULR1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
210
Total Number of Articles : 230 |
Description |
bone morphogenetic protein 4 |
| Gene Summary |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016] |
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