Protein Name alcohol dehydrogenase 5 (class III), chi polypeptide
Organism Homo sapiens
Gene ID 128
Gene Symbol

ADH5

UniProt P11766 (ADHX_HUMAN), Q6IRT1 (Q6IRT1_HUMAN)
Relationships Total Number of functionally related compound(s) : 164
Total Number of Articles : 174
Description

alcohol dehydrogenase 5 (class III), chi polypeptide

Gene Summary

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

synonyms
  • alcohol dehydrogenase class-3
  • S-(hydroxymethyl)glutathione dehydrogenase
  • S-nitrosoglutathione reductase
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Properties