| Protein Name | apoptotic peptidase activating factor 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 317 |
| Gene Symbol | APAF1 |
| UniProt | O14727 (APAF_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
241
Total Number of Articles : 317 |
Description |
apoptotic peptidase activating factor 1 |
| Gene Summary |
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| synonyms |
|
| Properties | |