Protein Name DEAD/H-box helicase 11
Organism Homo sapiens
Gene ID 1663
Gene Symbol

DDX11

UniProt Q96FC9 (DDX11_HUMAN), Q2NKM7 (Q2NKM7_HUMAN)
Relationships Total Number of functionally related compound(s) : 18
Total Number of Articles : 23
Description

DEAD/H-box helicase 11

Gene Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

synonyms
  • ATP-dependent DNA helicase DDX11
  • CHL1-like helicase homolog
  • CHL1-related helicase gene-1
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Properties