Protein Name tryptophanyl-tRNA synthetase 1
Organism Homo sapiens
Gene ID 7453
Gene Symbol

WARS1

UniProt P23381 (SYWC_HUMAN), A0A024R6K8 (A0A024R6K8_HUMAN)
Relationships Total Number of functionally related compound(s) : 246
Total Number of Articles : 286
Description

tryptophanyl-tRNA synthetase 1

Gene Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

synonyms
  • tryptophan--tRNA ligase, cytoplasmic
  • epididymis secretory sperm binding protein
  • hWRS
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Properties