Protein Name lysine demethylase 4B
Organism Homo sapiens
Gene ID 23030
Gene Symbol

KDM4B

UniProt O94953 (KDM4B_HUMAN), F5GX28 (F5GX28_HUMAN), A0A0C4DFL8 (A0A0C4DFL8_HUMAN)
Relationships Total Number of functionally related compound(s) : 37
Total Number of Articles : 37
Description

lysine demethylase 4B

Gene Summary

Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • lysine-specific demethylase 4B
  • [histone H3]-trimethyl-L-lysine(9) demethylase 4B
  • jmjC domain-containing histone demethylation protein 3B
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Properties