| Protein Name | eukaryotic translation initiation factor 2 subunit alpha |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1965 |
| Gene Symbol | EIF2S1 |
| UniProt | P05198 (IF2A_HUMAN), Q53XC0 (Q53XC0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
69
Total Number of Articles : 95 |
Description |
eukaryotic translation initiation factor 2 subunit alpha |
| Gene Summary |
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010] |
| synonyms |
|
| Properties | |