| Protein Name | sialic acid binding Ig like lectin 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 8778 |
| Gene Symbol | SIGLEC5 |
| UniProt | O15389 (SIGL5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
35
Total Number of Articles : 32 |
Description |
sialic acid binding Ig like lectin 5 |
| Gene Summary |
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
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