Protein Name peptidyl arginine deiminase 2
Organism Homo sapiens
Gene ID 11240
Gene Symbol


UniProt Q9Y2J8 (PADI2_HUMAN)
Relationships Total Number of functionally related compound(s) : 165
Total Number of Articles : 114

peptidyl arginine deiminase 2

Gene Summary

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

  • protein-arginine deiminase type-2
  • peptidyl arginine deiminase, type II
  • protein-arginine deiminase type II
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