Protein Name dopamine receptor D3
Organism Mus musculus
Gene ID 13490
Gene Symbol

Drd3

UniProt P30728 (DRD3_MOUSE), Q0VEC4 (Q0VEC4_MOUSE), A0A2R8VHF0 (A0A2R8VHF0_MOUSE)
Relationships Total Number of functionally related compound(s) : 93
Total Number of Articles : 141
Description

dopamine receptor D3

Gene Summary

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including regulation of blood pressure; regulation of dopamine receptor signaling pathway; and response to alkaloid. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • D(3) dopamine receptor
  • dopamine D3 receptor
  • dopamine receptor 3
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Properties