| Protein Name | dopamine receptor D3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13490 |
| Gene Symbol | Drd3 |
| UniProt | P30728 (DRD3_MOUSE), Q0VEC4 (Q0VEC4_MOUSE), A0A2R8VHF0 (A0A2R8VHF0_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
93
Total Number of Articles : 141 |
Description |
dopamine receptor D3 |
| Gene Summary |
Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; regulation of blood pressure; and regulation of dopamine receptor signaling pathway. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |