Protein Name TIMP metallopeptidase inhibitor 3
Organism Homo sapiens
Gene ID 7078
Gene Symbol

TIMP3

UniProt P35625 (TIMP3_HUMAN)
Relationships Total Number of functionally related compound(s) : 219
Total Number of Articles : 215
Description

TIMP metallopeptidase inhibitor 3

Gene Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]

synonyms
  • metalloproteinase inhibitor 3
  • MIG-5 protein
  • TIMP-3
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Properties