Protein Name NADH:ubiquinone oxidoreductase core subunit S4
Organism Mus musculus
Gene ID 17993
Gene Symbol

Ndufs4

UniProt Q9CXZ1 (NDUS4_MOUSE), E9QPX3 (E9QPX3_MOUSE)
Relationships Total Number of functionally related compound(s) : 41
Total Number of Articles : 37
Description

NADH:ubiquinone oxidoreductase core subunit S4

Gene Summary

Enables NADH dehydrogenase (ubiquinone) activity. Acts upstream of or within several processes, including adult walking behavior; mitochondrial respiratory chain complex I assembly; and nervous system development. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study Leigh disease and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
  • CI-18 kDa
  • CI-AQDQ
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Properties