Protein Name LDL receptor related protein 6
Organism Homo sapiens
Gene ID 4040
Gene Symbol


UniProt O75581 (LRP6_HUMAN)
Relationships Total Number of functionally related compound(s) : 111
Total Number of Articles : 121

LDL receptor related protein 6

Gene Summary

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]

  • low-density lipoprotein receptor-related protein 6
  • LRP-6
  • ADCAD2
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