| Protein Name | forkhead box A2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 15376 |
| Gene Symbol | Foxa2 |
| UniProt | P35583 (FOXA2_MOUSE), G5E8P5 (G5E8P5_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
59
Total Number of Articles : 74 |
Description |
forkhead box A2 |
| Gene Summary |
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of detection of glucose; negative regulation of glucokinase activity; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of neuron differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; endoderm; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2). [provided by Alliance of Genome Resources, Apr 2022] |
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