| Protein Name | tet methylcytosine dioxygenase 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 214133 |
| Gene Symbol | Tet2 |
| UniProt | Q4JK59 (TET2_MOUSE), A0A0G2JF55 (A0A0G2JF55_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
70
Total Number of Articles : 86 |
Description |
tet methylcytosine dioxygenase 2 |
| Gene Summary |
Enables methylcytosine dioxygenase activity. Involved in cellular protein modification process; myeloid cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including DNA demethylation; animal organ development; and hematopoietic stem cell homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022] |
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