| Protein Name | cryptochrome circadian regulator 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1407 |
| Gene Symbol | CRY1 |
| UniProt | Q16526 (CRY1_HUMAN), A2I2P0 (A2I2P0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
73
Total Number of Articles : 65 |
Description |
cryptochrome circadian regulator 1 |
| Gene Summary |
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014] |
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