CPRiL

SIRT5

sirtuin 5

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

• NAD-dependent protein deacylase sirtuin-5, mitochondrial
• NAD-dependent deacetylase sirtuin-5
• NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
silent mating type information regulation 2, S.cerevisiae, homolog 5
sir2-like 5
sirtuin type 5
SIR2L5