Protein Name sirtuin 5
Organism Homo sapiens
Gene ID 23408
Gene Symbol


UniProt Q9NXA8 (SIR5_HUMAN), A0A024R012 (A0A024R012_HUMAN)
Relationships Total Number of functionally related compound(s) : 102
Total Number of Articles : 105

sirtuin 5

Gene Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

  • NAD-dependent protein deacylase sirtuin-5, mitochondrial
  • NAD-dependent deacetylase sirtuin-5
  • NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
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