Protein Name | SMAD family member 7 |
---|---|
Organism | Homo sapiens |
Gene ID | 4092 |
Gene Symbol | SMAD7 |
UniProt | O15105 (SMAD7_HUMAN), B3KYA8 (B3KYA8_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
182
Total Number of Articles : 225 |
Description |
SMAD family member 7 |
Gene Summary |
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
synonyms |
|
Properties | |