Protein Name SMAD family member 7
Organism Homo sapiens
Gene ID 4092
Gene Symbol

SMAD7

UniProt O15105 (SMAD7_HUMAN), B3KYA8 (B3KYA8_HUMAN)
Relationships Total Number of functionally related compound(s) : 182
Total Number of Articles : 225
Description

SMAD family member 7

Gene Summary

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

synonyms
  • mothers against decapentaplegic homolog 7
  • MAD (mothers against decapentaplegic, Drosophila) homolog 7
  • MAD homolog 8
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Properties