Protein Name STIP1 homology and U-box containing protein 1
Organism Homo sapiens
Gene ID 10273
Gene Symbol

STUB1

UniProt Q9UNE7 (CHIP_HUMAN)
Relationships Total Number of functionally related compound(s) : 17
Total Number of Articles : 17
Description

STIP1 homology and U-box containing protein 1

Gene Summary

This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

synonyms
  • E3 ubiquitin-protein ligase CHIP
  • CLL-associated antigen KW-8
  • RING-type E3 ubiquitin transferase CHIP
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Properties