Protein Name HNF1 homeobox A
Organism Homo sapiens
Gene ID 6927
Gene Symbol


UniProt P20823 (HNF1A_HUMAN), E0YMI7 (E0YMI7_HUMAN)
Relationships Total Number of functionally related compound(s) : 187
Total Number of Articles : 332

HNF1 homeobox A

Gene Summary

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

  • hepatocyte nuclear factor 1-alpha
  • albumin proximal factor
  • hepatic nuclear factor 1
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