| Protein Name | nuclear receptor subfamily 3, group C, member 2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25672 |
| Gene Symbol | Nr3c2 |
| UniProt | P22199 (MCR_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
199
Total Number of Articles : 425 |
Description |
nuclear receptor subfamily 3, group C, member 2 |
| Gene Summary |
Enables several functions, including DNA binding activity; histone acetyltransferase binding activity; and transcription coactivator binding activity. Involved in several processes, including nuclear receptor-mediated corticosteroid signaling pathway; positive regulation of transcription by RNA polymerase II; and response to mineralocorticoid. Located in cytoplasm and nucleus. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Used to study alcohol use disorder; morphine dependence; and polycystic ovary syndrome. Biomarker of alcohol dependence; fetal alcohol spectrum disorder; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1; opioid abuse; and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |