| Protein Name | leucine rich repeat kinase 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 120892 |
| Gene Symbol | LRRK2 |
| UniProt | Q5S007 (LRRK2_HUMAN), Q17RV3 (Q17RV3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
270
Total Number of Articles : 431 |
Description |
leucine rich repeat kinase 2 |
| Gene Summary |
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] |
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