| Protein Name | zinc finger E-box binding homeobox 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 21417 |
| Gene Symbol | Zeb1 |
| UniProt | Q64318 (ZEB1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
75
Total Number of Articles : 62 |
Description |
zinc finger E-box binding homeobox 1 |
| Gene Summary |
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuron differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; negative regulation of keratinocyte proliferation; and regulation of T cell differentiation in thymus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study HTLV-1-associated myelopathy/tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Jun 2025] |
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