Protein Name LIF interleukin 6 family cytokine
Organism Homo sapiens
Gene ID 3976
Gene Symbol


UniProt P15018 (LIF_HUMAN)
Relationships Total Number of functionally related compound(s) : 950
Total Number of Articles : 1152

LIF interleukin 6 family cytokine

Gene Summary

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

  • leukemia inhibitory factor
  • D factor
  • cholinergic differentiation factor
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