Protein Name BMI1 proto-oncogene, polycomb ring finger
Organism Homo sapiens
Gene ID 648
Gene Symbol

BMI1

UniProt P35226 (BMI1_HUMAN)
Relationships Total Number of functionally related compound(s) : 209
Total Number of Articles : 295
Description

BMI1 proto-oncogene, polycomb ring finger

Gene Summary

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]

synonyms
  • polycomb complex protein BMI-1
  • B lymphoma Mo-MLV insertion region 1 homolog
  • BMI1 polycomb ring finger oncogene
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Properties