Protein Name solute carrier family 1 member 1
Organism Homo sapiens
Gene ID 6505
Gene Symbol

SLC1A1

UniProt P43005 (EAA3_HUMAN)
Relationships Total Number of functionally related compound(s) : 133
Total Number of Articles : 191
Description

solute carrier family 1 member 1

Gene Summary

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

synonyms
  • excitatory amino acid transporter 3
  • excitatory amino acid carrier 1
  • neuronal and epithelial glutamate transporter
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Properties