CPRiL

Protein Name	sodium voltage-gated channel alpha subunit 5
Organism	Rattus norvegicus
Gene ID	25665
Gene Symbol	Scn5a
UniProt	P15389 (SCN5A_RAT), A0A0G2JWG8 (A0A0G2JWG8_RAT), F1LPK3 (F1LPK3_RAT)
Relationships	Total Number of functionally related compound(s) : 59 Total Number of Articles : 57
Description	sodium voltage-gated channel alpha subunit 5
Gene Summary	Enables ankyrin binding activity; fibroblast growth factor binding activity; and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in several processes, including brain development; response to denervation involved in regulation of muscle adaptation; and sodium ion import across plasma membrane. Located in T-tubule and intercalated disc. Biomarker of brain ischemia and congestive heart failure. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and sudden infant death syndrome. Orthologous to human SCN5A (sodium voltage-gated channel alpha subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
synonyms	sodium channel protein type 5 subunit alpha skeletal muscle voltage-sensitive sodium channel subtype 2 sodium channel protein cardiac muscle subunit alpha sodium channel protein type V subunit alpha sodium channel, voltage-gated, type 5, alpha subunit sodium channel, voltage-gated, type V, alpha polypeptide sodium channel, voltage-gated, type V, alpha subunit voltage-gated sodium channel Nav1.5c voltage-gated sodium channel subunit alpha Nav1.5 Nav1.5 RATRSKM2X RSKM2X SCAL Scn2x rSkM2 Click to show/hide the synonyms
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