Protein Name | splicing factor 3b subunit 1 |
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Organism | Homo sapiens |
Gene ID | 23451 |
Gene Symbol | SF3B1 |
UniProt | O75533 (SF3B1_HUMAN), B4DGZ4 (B4DGZ4_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
71
Total Number of Articles : 87 |
Description |
splicing factor 3b subunit 1 |
Gene Summary |
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
synonyms |
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Properties | |