Protein Name splicing factor 3b subunit 1
Organism Homo sapiens
Gene ID 23451
Gene Symbol


UniProt O75533 (SF3B1_HUMAN), B4DGZ4 (B4DGZ4_HUMAN)
Relationships Total Number of functionally related compound(s) : 71
Total Number of Articles : 87

splicing factor 3b subunit 1

Gene Summary

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

  • splicing factor 3B subunit 1
  • pre-mRNA processing 10
  • pre-mRNA splicing factor SF3b, 155 kDa subunit
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