| Protein Name | purinergic receptor P2Y, G-protein coupled 12 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 70839 |
| Gene Symbol | P2ry12 |
| UniProt | Q9CPV9 (P2Y12_MOUSE), Q546L4 (Q546L4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
66
Total Number of Articles : 104 |
Description |
purinergic receptor P2Y, G-protein coupled 12 |
| Gene Summary |
Enables G protein-coupled ADP receptor activity and G protein-coupled adenosine receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway; platelet activation; and positive regulation of monoatomic ion transport. Located in cell body membrane and cell projection membrane. Is expressed in central nervous system and cerebral cortex. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Jul 2025] |
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