| Protein Name | excision repair cross-complementing rodent repair deficiency, complementation group 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13870 |
| Gene Symbol | Ercc1 |
| UniProt | P07903 (ERCC1_MOUSE), E9PUM0 (E9PUM0_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
39
Total Number of Articles : 36 |
Description |
excision repair cross-complementing rodent repair deficiency, complementation group 1 |
| Gene Summary |
Enables TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Involved in positive regulation of t-circle formation and t-circle formation. Acts upstream of or within several processes, including DNA metabolic process; UV protection; and determination of adult lifespan. Is active in nucleus. Is expressed in several structures, including brain; genitourinary system; liver; skin; and spleen. Used to study XFE progeroid syndrome. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit). [provided by Alliance of Genome Resources, Jun 2025] |
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