| Protein Name | carboxypeptidase E |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1363 |
| Gene Symbol | CPE |
| UniProt | P16870 (CBPE_HUMAN), A0A384N679 (A0A384N679_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
400
Total Number of Articles : 268 |
Description |
carboxypeptidase E |
| Gene Summary |
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015] |
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