| Protein Name | syntaxin 1A |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6804 |
| Gene Symbol | STX1A |
| UniProt | Q16623 (STX1A_HUMAN), Q75ME0 (Q75ME0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
123
Total Number of Articles : 134 |
Description |
syntaxin 1A |
| Gene Summary |
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
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| Properties | |