Protein Name | ADAM metallopeptidase with thrombospondin type 1 motif 13 |
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Organism | Homo sapiens |
Gene ID | 11093 |
Gene Symbol | ADAMTS13 |
UniProt | Q76LX8 (ATS13_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
172
Total Number of Articles : 261 |
Description |
ADAM metallopeptidase with thrombospondin type 1 motif 13 |
Gene Summary |
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
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