Protein Name ADAM metallopeptidase with thrombospondin type 1 motif 13
Organism Homo sapiens
Gene ID 11093
Gene Symbol

ADAMTS13

UniProt Q76LX8 (ATS13_HUMAN)
Relationships Total Number of functionally related compound(s) : 172
Total Number of Articles : 261
Description

ADAM metallopeptidase with thrombospondin type 1 motif 13

Gene Summary

This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

synonyms
  • A disintegrin and metalloproteinase with thrombospondin motifs 13
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
  • vWF-cleaving protease
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Properties