Protein Name F2R like trypsin receptor 1
Organism Homo sapiens
Gene ID 2150
Gene Symbol


UniProt P55085 (PAR2_HUMAN)
Relationships Total Number of functionally related compound(s) : 329
Total Number of Articles : 393

F2R like trypsin receptor 1

Gene Summary

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

  • proteinase-activated receptor 2
  • G-protein coupled receptor 11
  • coagulation factor II (thrombin) receptor-like 1
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