Protein Name Rap guanine nucleotide exchange factor 4
Organism Rattus norvegicus
Gene ID 252857
Gene Symbol

Rapgef4

UniProt D3KR63 (D3KR63_RAT)
Relationships Total Number of functionally related compound(s) : 23
Total Number of Articles : 36
Description

Rap guanine nucleotide exchange factor 4

Gene Summary

Enables cAMP binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including nervous system development; positive regulation of neuronal action potential; and regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; brush border; and distal axon. Part of protein-containing complex. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • rap guanine nucleotide exchange factor 4
  • Rap guanine nucleotide exchange factor (GEF) 4
  • cAMP-regulated guanine nucleotide exchange factor II
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Properties