Protein Name hydroxysteroid 11-beta dehydrogenase 1
Organism Rattus norvegicus
Gene ID 25116
Gene Symbol

Hsd11b1

UniProt P16232 (DHI1_RAT)
Relationships Total Number of functionally related compound(s) : 165
Total Number of Articles : 177
Description

hydroxysteroid 11-beta dehydrogenase 1

Gene Summary

Enables NADP binding activity and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; glucocorticoid metabolic process; and regulation of pentose-phosphate shunt. Located in apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Used to study obesity. Biomarker of familial hyperlipidemia; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cortisone reductase deficiency and cortisone reductase deficiency 2. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • 11-beta-hydroxysteroid dehydrogenase 1
  • 11-DH
  • 11-beta-HSD1
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Properties