CPRiL

Oas1b

2'-5' oligoadenylate synthetase 1B

This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]

• inactive 2'-5'-oligoadenylate synthase 1B
• (2-5')oligo(A) synthase 1B
• (2-5')oligo(A) synthetase 1b
2'-5'-oligoadenylate synthase-like protein 1
2'-5'-oligoadenylate synthetase-like protein 1
2-5A synthase 1B
2-5A synthetase 1B
Flavivirus resistance
Flv
L1
Mmu-L1
Oas1
Oias-2
Oias2
Wnv