Protein Name solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Organism Mus musculus
Gene ID 15567
Gene Symbol

Slc6a4

UniProt Q60857 (SC6A4_MOUSE)
Relationships Total Number of functionally related compound(s) : 206
Total Number of Articles : 302
Description

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Gene Summary

Enables monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and nitric-oxide synthase binding activity. Involved in several processes, including brain morphogenesis; serotonin uptake; and social behavior. Acts upstream of or within cellular response to organic substance. Located in focal adhesion and synapse. Is expressed in several structures, including early conceptus; liver; nervous system; ovary; and polar body. Used to study autism spectrum disorder and sudden infant death syndrome. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • sodium-dependent serotonin transporter
  • 5-hydroxytryptamine (serotonin) transporter
  • 5HT transporter
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Properties