Protein Name | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase |
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Organism | Homo sapiens |
Gene ID | 4249 |
Gene Symbol | MGAT5 |
UniProt | Q09328 (MGT5A_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
165
Total Number of Articles : 195 |
Description |
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase |
Gene Summary |
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011] |
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