| Protein Name | E2F transcription factor 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13555 |
| Gene Symbol | E2f1 |
| UniProt | Q61501 (E2F1_MOUSE), Q547J6 (Q547J6_MOUSE), Q9CYB4 (Q9CYB4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
102
Total Number of Articles : 108 |
Description |
E2F transcription factor 1 |
| Gene Summary |
Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; and transcription, DNA-templated. Acts upstream of or within several processes, including anoikis; intrinsic apoptotic signaling pathway by p53 class mediator; and lens fiber cell apoptotic process. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022] |
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