Protein Name NME/NM23 nucleoside diphosphate kinase 1
Organism Homo sapiens
Gene ID 4830
Gene Symbol


UniProt P15531 (NDKA_HUMAN), A0A384MTW7 (A0A384MTW7_HUMAN)
Relationships Total Number of functionally related compound(s) : 245
Total Number of Articles : 267

NME/NM23 nucleoside diphosphate kinase 1

Gene Summary

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

  • nucleoside diphosphate kinase A
  • NDP kinase A
  • epididymis secretory sperm binding protein
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