Protein Name methylenetetrahydrofolate reductase
Organism Mus musculus
Gene ID 17769
Gene Symbol

Mthfr

UniProt Q9WU20 (MTHR_MOUSE), A2A7F7 (A2A7F7_MOUSE), Q3UDB2 (Q3UDB2_MOUSE), Q497H7 (Q497H7_MOUSE)
Relationships Total Number of functionally related compound(s) : 73
Total Number of Articles : 88
Description

methylenetetrahydrofolate reductase

Gene Summary

Enables methylenetetrahydrofolate reductase (NAD(P)H) activity. Acts upstream of or within methionine biosynthetic process. Predicted to be located in synapse. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; cranium; heart; sensory organ; and testis. Used to study neural tube defect. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • methylenetetrahydrofolate reductase (NADPH)
  • 5,10-methylenetetrahydrofolate reductase
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Properties