| Protein Name | transmembrane channel-like gene family 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13409 |
| Gene Symbol | Tmc1 |
| UniProt | Q8R4P5 (TMC1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
20
Total Number of Articles : 13 |
Description |
transmembrane channel-like gene family 1 |
| Gene Summary |
Enables mechanosensitive monoatomic ion channel activity and voltage-gated calcium channel activity. Acts upstream of or within several processes, including auditory receptor cell development; detection of mechanical stimulus involved in sensory perception of sound; and vestibular reflex. Located in external side of plasma membrane and stereocilium tip. Is expressed in sensory organ and skeleton. Used to study autosomal dominant nonsyndromic deafness 36 and autosomal recessive nonsyndromic deafness 7. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to human TMC1 (transmembrane channel like 1). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |