Protein Name | transient receptor potential cation channel, subfamily V, member 4 |
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Organism | Rattus norvegicus |
Gene ID | 66026 |
Gene Symbol | Trpv4 |
UniProt | Q9ERZ8 (TRPV4_RAT) |
Relationships |
Total Number of functionally related compound(s) :
144
Total Number of Articles : 160 |
Description |
transient receptor potential cation channel, subfamily V, member 4 |
Gene Summary |
Enables calcium channel activity; cytoskeletal protein binding activity; and protein kinase C binding activity. Involved in several processes, including calcium ion transport; cytoskeleton organization; and positive regulation of microtubule depolymerization. Located in several cellular components, including focal adhesion; lamellipodium; and ruffle membrane. Colocalizes with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2022] |
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Properties | |