Protein Name transient receptor potential cation channel, subfamily V, member 4
Organism Rattus norvegicus
Gene ID 66026
Gene Symbol

Trpv4

UniProt Q9ERZ8 (TRPV4_RAT)
Relationships Total Number of functionally related compound(s) : 144
Total Number of Articles : 160
Description

transient receptor potential cation channel, subfamily V, member 4

Gene Summary

Enables calcium channel activity; cytoskeletal protein binding activity; and protein kinase C binding activity. Involved in several processes, including calcium ion transport; cytoskeleton organization; and positive regulation of microtubule depolymerization. Located in several cellular components, including focal adhesion; lamellipodium; and ruffle membrane. Colocalizes with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • transient receptor potential cation channel subfamily V member 4
  • VR-OAC
  • osm-9-like TRP channel 4
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Properties