Protein Name ATP binding cassette subfamily E member 1
Organism Homo sapiens
Gene ID 6059
Gene Symbol

ABCE1

UniProt P61221 (ABCE1_HUMAN)
Relationships Total Number of functionally related compound(s) : 142
Total Number of Articles : 79
Description

ATP binding cassette subfamily E member 1

Gene Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

synonyms
  • ATP-binding cassette sub-family E member 1
  • 2'-5'-oligoadenylate-binding protein
  • ATP-binding cassette, sub-family E (OABP), member 1
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Properties