| Protein Name | parkin RBR E3 ubiquitin protein ligase |
|---|---|
| Organism | Mus musculus |
| Gene ID | 50873 |
| Gene Symbol | Prkn |
| UniProt | Q9WVS6 (PRKN_MOUSE), A0A3B2W489 (A0A3B2W489_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
40
Total Number of Articles : 36 |
Description |
parkin RBR E3 ubiquitin protein ligase |
| Gene Summary |
Enables ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; positive regulation of dendrite extension; and positive regulation of protein metabolic process. Acts upstream of or within several processes, including catecholamine metabolic process; chemical synaptic transmission; and startle response. Located in mitochondrion; neuron projection; and nucleus. Part of protein-containing complex. Is active in dopaminergic synapse. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |