| Protein Name | SRY (sex determining region Y)-box 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 20674 |
| Gene Symbol | Sox2 |
| UniProt | P48432 (SOX2_MOUSE), Q60I23 (Q60I23_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
170
Total Number of Articles : 200 |
Description |
SRY (sex determining region Y)-box 2 |
| Gene Summary |
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). [provided by RefSeq, Sep 2015] |
| synonyms |
|
| Properties | |