| Protein Name | toll-like receptor 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 142980 |
| Gene Symbol | Tlr3 |
| UniProt | Q99MB1 (TLR3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
150
Total Number of Articles : 353 |
Description |
toll-like receptor 3 |
| Gene Summary |
Enables pattern recognition receptor activity; transmembrane signaling receptor activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of macromolecule biosynthetic process; and response to virus. Acts upstream of or within several processes, including cellular response to exogenous dsRNA; positive regulation of JNK cascade; and regulation of cytokine production. Is active in plasma membrane. Is expressed in blood; brain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; liver disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |